This article or plot contains spoilers from the actual game. If you do not wish to be spoiled, do not read it.
The Talk is a mission in South Park: The Fractured But Whole.
After leaving the South Park Church, go left to head over to South Park Elementary and when you get there, punch the snowman in front of the building to get an Arcane Hat and activate the Fast Travel point to the right before entering the school.
Once inside the school, take selfies with Ashley and Annie next to the stairs. Mr. Adler will only take a selfie with you if you "stop screwing around", just don't press any buttons for a few seconds after you request to take a selfie with him.
Head through the hall and enter the counselor's office to find Mr. Mackey. Here you can choose your Sex/Gender and you can change it anytime you want too!
For this first talk, you're only able to pick one of the gender options as below:
If Male or Female were to be picked, another two options will be given, consisting of:
Once you have completed determining your Sex/Gender, you may proceed to leave the counselor's office.
Before leaving the school, loot the gymnasium where you can find another piece of Creek Yaoi Art.
Once you go outside, a bunch of rednecks will attack you regardless of what gender you have selected. Defeat the rednecks and you will get the Hate Forge artifact as a reward; the mission will then be complete.